On a cycle of 500+ mg of testosterone per week, my estradiol levels have skyrocketed—my breasts have started to swell, I’m retaining water, my mood is all over the place, and my face is puffy. Anastrozole isn’t cutting it, even at a higher dose. I’m thinking of switching to letrozole, since I’ve heard it knocks down estradiol more aggressively. Has anyone used letrozole on a cycle? How quickly does it work, and does it knock it down too hard?